The Nitty Gritty of Global Harmonization (w/ Special Guest, Karla Moncada)
In this episode, the hosts introduce Karla Moncada, who shares her professional journey from Flowcore management to her current role at KCAS, and unveils her new KCAS video series, Karla’s Corner, aimed at fostering year-round conversations within the flow cytometry community. Karla emphasizes the value of personal connections in scientific collaboration and how her career has blended customer service with cutting-edge science. The main topic of the episode focuses on global harmonization in flow cytometry, particularly in phenotyping myeloid-derived suppressor cells (MDSCs) across 23 international labs. The discussion highlights challenges such as inconsistent gating strategies, variations in reagent availability, and difficulties standardizing instrumentation and regulatory compliance across geographies. The group explores how differences in equipment setup and panel design can lead to significant inter-lab variability in data. The episode underscores the need for harmonized protocols to achieve reproducibility and reliability in global collaborative studies.“The Conversational Flow” an official podcast of KCAS Bio, and focuses on the more niche topic of Flow Cytometry and its role within the greater pharmaceutical, biopharmaceutical and bioanalytical industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Flow Cytometry experts as they chat over coffee and discuss what they’ve learned about the world of Flow Cytometry the past couple of weeks. “The Conversational Flow” is brought to you by KCAS Bio.KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries.
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Flow Cytometry & Autoimmunity – A High Affinity Pharmacodynamic Match
In episode 21 of “The Conversational Flow” podcast, our hosts, Adam and Brian, explore the transformative power of gene therapy, starting things off by highlighting a compelling case involving CRISPR with milestones that once seemed impossible. They dive into the science behind CRISPR’s precise gene-editing capabilities and its potential for rapid, customizable treatments targeting rare and complex genetic mutations. The conversation also touches on the broader landscape of gene therapy delivery mechanisms and how advances are gradually expanding what's possible for more patients. Shifting gears, they critically examine recent vaccine policy developments and express concern about anti-scientific sentiment influencing public health. This is one episode you will definitely enjoy.“The Conversational Flow” an official podcast of KCAS Bio, and focuses on the more niche topic of Flow Cytometry and its role within the greater pharmaceutical, biopharmaceutical and bioanalytical industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Flow Cytometry experts as they chat over coffee and discuss what they’ve learned about the world of Flow Cytometry the past couple of weeks. “The Conversational Flow” is brought to you by KCAS Bio.KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries.
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Impactful Developments Across Oncology and Regulatory Science
In this milestone 20th episode of The Conversational Flow, hosts Adam and Brian dive into impactful developments across oncology, regulatory science, and bioanalytical innovation. The episode highlig4 hts a major Keytruda study showing the first significant improvement in head and neck squamous cell carcinoma outcomes in over two decades, the FDA’s pilot integration of generative AI in scientific review processes, and Sanofi’s acquisition of AI-developed bispecific antibodies for autoimmune diseases. The conversation rounds out with thoughtful discussion on data harmonization across multicenter flow cytometry studies and updates on KCAS’s scientific contributions at CYTO and regional events.“The Conversational Flow” an official podcast of KCAS Bio, and focuses on the more niche topic of Flow Cytometry and its role within the greater pharmaceutical, biopharmaceutical and bioanalytical industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Flow Cytometry experts as they chat over coffee and discuss what they’ve learned about the world of Flow Cytometry the past couple of weeks. “The Conversational Flow” is brought to you by KCAS Bio.KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries.
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Building on Backbone Panels: Standardization, Speed, and Integration
In the 19th episode of “The Conversational Flow”, our hosts, Brian and Adam, dive into the utility and innovation behind backbone panels in spectral flow cytometry, spotlighting a recent paper from BMS that presents a robust, flexible assay designed for immune monitoring using the Aurora platform. They discuss how backbone panels streamline assay development, enhance reproducibility, and are well-suited for integration with AI-driven gating strategies. The conversation also touches on industry trends shared at WRIB, including the push toward global harmonization of instruments and standards in clinical trials. With insights on panel optimization, autofluorescence extraction, and metadata standardization, the episode offers a practical look at how backbone panels are shaping the future of flow cytometry.“The Conversational Flow” an official podcast of KCAS Bio, and focuses on the more niche topic of Flow Cytometry and its role within the greater pharmaceutical, biopharmaceutical and bioanalytical industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Flow Cytometry experts as they chat over coffee and discuss what they’ve learned about the world of Flow Cytometry the past couple of weeks. “The Conversational Flow” is brought to you by KCAS Bio.KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries.
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Flow Cytometry & Cell Therapy: One Cell Can Make a World of Difference
In this engaging episode of the podcast, hosts Brian Wile and Adam Cotty welcome special guests Michael Naso, Hillary Quinn, and Barry Morse from The Therapeutic Innovations Group—a powerhouse team of scientists and biotech veterans with decades of experience across biologics, small molecules, and cell therapy. The conversation dives deep into the guests’ unique career journeys, and their own consulting venture aimed at helping startups and academic teams navigate early-stage biotech development. Along the way, listeners are treated to insider stories, genuine camaraderie, and valuable insights into cutting-edge topics like CAR-T cell analysis, flow cytometry, and the evolving landscape of cell therapy. Whether you're a biotech professional or just biotech-curious, this episode delivers science, strategy, and plenty of laughs—don't miss it!“The Conversational Flow” an official podcast of KCAS Bio, and focuses on the more niche topic of Flow Cytometry and its role within the greater pharmaceutical, biopharmaceutical and bioanalytical industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Flow Cytometry experts as they chat over coffee and discuss what they’ve learned about the world of Flow Cytometry the past couple of weeks. “The Conversational Flow” is brought to you by KCAS Bio.KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries.
Sobre The Conversational Flow - An Official Podcast of KCAS
"The Conversational Flow" an official podcast of KCAS Bioanalytical and Biomarker Services, and focuses on the more niche topic of Flow Cytometry and its role within the greater pharmaceutical, biopharmaceutical and bioanalytical industries.. Every month, KCAS will bring you another 60 minutes (or so) of friendly banter between our two finest Flow Cytometry experts as they chat over coffee and discuss what they've learned about the world of Flow Cytometry the past couple of weeks. The Weekly Bioanalysis is brought to you by KCAS.KCAS is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the Pharmaceutical, Biopharmaceutical, Animal Health and Medical Device industries.
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