190 episódios
- Ben Lamm is the Co-founder and CEO of Colossal Biosciences + their AI spinout, Astromech. Colossal is the $12 billion de-extinction company using genome engineering, AI and reproductive technologies to bring extinct species back to life, while Astromech is its AI biology spinout, now valued at $3.8 billion.
We went inside Colossal’s lab to see its Gen 2 woolly mice and sat down with Ben to discuss the technology behind the dire wolf, the race to bring back the woolly mammoth, and the much bigger business being built underneath de-extinction.
Colossal has raised $635 million, including a recent $400 million round that was originally targeted at $200 million. Ben explains why he still believes Colossal is “one of the most undervalued companies in the world,” and how technologies developed inside the company are creating entirely new businesses.
Astromech, the AI biology spinout Co-founded by Lamm and George Church, just raised $20 million at a $3.8 billion valuation, bringing total funding to $60 million. Astromech is using evolutionary and multispecies genomic data to build AI models designed to predict biological change, with potential applications across cancer, disease and drug discovery.
We cover Colossal’s rise, woolly mice, dire wolves, mammoths, artificial wombs, genome editing, AI and biology, Astromech, and what happens when humans learn to program life.
Ben Lamm: https://x.com/BenLamm
Molly O’Shea: https://x.com/MollySOShea
Sourcery: https://x.com/sourceryy
𝐄𝐏𝐈𝐒𝐎𝐃𝐄 𝐋𝐈𝐍𝐊
YouTube: https://youtu.be/zCQuSExl0gI
𝐒𝐏𝐎𝐍𝐒𝐎𝐑𝐒
• Brex—The modern finance platform, combining the world’s smartest corporate card with integrated expense management, banking, bill pay, & travel. https://brex.com/sourcery
• Turing—Turing delivers top-tier talent, data, and tools to help AI labs improve model performance—and enables enterprises to turn those models into powerful, production-ready systems. https://turing.com/sourcery
• VCX—VCX is the public ticker for private tech, allowing investors of all sizes to invest in venture capital. View The Portfolio at http://GetVCX.com
• Deel—Deel is the global people platform that helps startups hire, manage, pay, and equip anyone, anywhere. Trusted by more than 35,000 fast-growing companies, Deel is the people platform that just works, so teams can scale without the chaos. Visit: https://www.deel.com/sourcery
• Public–Investing platform Public just launched Generated Assets, which lets you turn any idea into an investable index with AI. With Generated Assets, you can build, backtest, refine, and invest in any thesis with AI. Gone are the days of one-size-fits-all ETFs. https://public.com/sourcery
Follow Sourcery for the latest updates!
https://www.sourcery.vc
Disclosure
Paid Endorsement. Brokerage services by Open to the Public Investing Inc, member FINRA & SIPC. Advisory services by Public Advisors LLC, SEC-registered adviser. Crypto trading provided by Zero Hash LLC, licensed by the NYSDFS. Generated Assets is an interactive analysis tool by Public Advisors. Output is for informational purposes only and is not an investment recommendation or advice. See disclosures at public.com/disclosures/ga. Matched funds must remain in your account for at least 5 years. Match rate and other terms are subject to change at any time.
𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒
(00:00) Ben Lamm, Co-Founder & CEO at Colossal Biosciences
(01:07) Inside Colossal's De-Extinction Lab
(06:02) The AI idea that could save the planet
(08:28) Revealing Colossal's woolly mice
(10:49) Wild requests they get every day
(13:35) Colossal's business model
(15:07) How Colossal raised $635 million
(20:17) How AI is converging with Biotech
(22:44) How ancient DNA actually gets to the lab
(26:24) The real stats behind Mass Extinction
(32:07) Will their animals ever live in the wild?
(41:44) Choosing their earliest backers
(52:51) Why they refuse to work on Humans
(58:07) Are they secretly working on Aliens? - Nikesh Arora is the Chairman and CEO of Palo Alto Networks, the cybersecurity giant that has grown from roughly $18 billion in market cap when he joined to around $300 billion today.
We sat down at Palo Alto Networks to discuss why Nikesh believes the AI cybersecurity boom is only beginning, how companies will defend themselves against increasingly powerful AI attacks and rogue agents, and why the time between discovering a vulnerability and exploiting it is collapsing.
Nikesh also explains why he signed Jensen Huang’s recent open-source AI letter, what the rise of autonomous agents means for enterprise security, and why he believes the entire software industry will be rewritten over the next decade.
We also go inside the operating playbook behind Palo Alto Networks’ rise, including 40+ acquisitions in eight years, the $28 billion CyberArk deal, Nikesh’s “paranoia” about disruption, hiring AI-native talent through hackathons, and the lessons he took from Larry Page at Google and Masayoshi Son at SoftBank.
Nikesh Arora: https://x.com/nikesharora
Molly O’Shea: https://x.com/MollySOShea
Sourcery: https://x.com/sourceryy
𝐄𝐏𝐈𝐒𝐎𝐃𝐄 𝐋𝐈𝐍𝐊
YouTube: https://youtu.be/_v_ryYwmfM0
𝐒𝐏𝐎𝐍𝐒𝐎𝐑𝐒
• Brex—The modern finance platform, combining the world’s smartest corporate card with integrated expense management, banking, bill pay, & travel. https://brex.com/sourcery
• Turing—Turing delivers top-tier talent, data, and tools to help AI labs improve model performance—and enables enterprises to turn those models into powerful, production-ready systems. https://turing.com/sourcery
• VCX—VCX is the public ticker for private tech, allowing investors of all sizes to invest in venture capital. View The Portfolio at http://GetVCX.com
• Deel—Deel is the global people platform that helps startups hire, manage, pay, and equip anyone, anywhere. Trusted by more than 35,000 fast-growing companies, Deel is the people platform that just works, so teams can scale without the chaos. Visit: https://www.deel.com/sourcery
• Public–Investing platform Public just launched Generated Assets, which lets you turn any idea into an investable index with AI. With Generated Assets, you can build, backtest, refine, and invest in any thesis with AI. Gone are the days of one-size-fits-all ETFs. https://public.com/sourcery
Follow Sourcery for the latest updates!
https://www.sourcery.vc
Disclosure
Paid Endorsement. Brokerage services by Open to the Public Investing Inc, member FINRA & SIPC. Advisory services by Public Advisors LLC, SEC-registered adviser. Crypto trading provided by Zero Hash LLC, licensed by the NYSDFS. Generated Assets is an interactive analysis tool by Public Advisors. Output is for informational purposes only and is not an investment recommendation or advice. See disclosures at public.com/disclosures/ga. Matched funds must remain in your account for at least 5 years. Match rate and other terms are subject to change at any time.
𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒
(00:00) Nikesh Arora, Chairman & CEO at Palo Alto Networks
(00:51) The AI attack era has already started
(03:30) What happens when agents go rogue
(04:39) Why AI Labs are slowing down
(06:31) The Mythos Fallout
(17:25) Cybersecurity's secret weapon
(19:43) Buying a company is the easy part
(20:48) Where most acquisitions go wrong
(24:58) Predicting the SaaS Crash?
(28:03) The question nobody in Tech is asking
(30:54) There's never enough Compute
(33:12) Palo Alto's bar for AI fluency
(35:37) The controversial hire
(37:12) Using LinkedIn to spot opportunities
(39:19) What a CEO's day actually looks like
(43:47) The leadership traits that matter
(47:02) Google vs. SoftBank: What was different?
(51:02) Why planning horizons are shrinking
(52:55) Lessons From Elon & Masa
(56:44) What's next for Nikesh? - Adam Foroughi, Co-Founder & CEO of AppLovin, and Giovanni Ge, CTO of AppLovin, join Sourcery from AppLovin’s Palo Alto headquarters for a deep dive into the technology and strategy behind its advertising business.
Gio joined AppLovin in late 2022, when the company was worth roughly $5.5 billion, and helped architect Axon 2, the recommendation engine that became central to AppLovin’s transformation. The new architecture improved predictions and advertiser returns, helping drive the company’s expansion beyond mobile gaming into e-commerce ads and its recovery from a 92% post-IPO decline to a $100B+ company.
Adam and Gio break down how Axon works, how AppLovin scales with a remarkably lean engineering team, how AI is changing the way they build, why knowing what not to build matters, and what it would take for AppLovin to eventually become a trillion-dollar company.
We also cover AppLovin’s expansion into e-commerce, the future of advertising across LLMs and connected TV, engineering culture, and how they think about building for the next five to ten years.
Adam Foroughi: https://www.linkedin.com/in/adamforoughi/
Giovanni Ge: https://www.linkedin.com/in/xiaochuan-giovanni-ge/
Molly O’Shea: https://x.com/MollySOShea
Sourcery: https://x.com/sourceryy
𝐄𝐏𝐈𝐒𝐎𝐃𝐄 𝐋𝐈𝐍𝐊
YouTube: https://youtu.be/IZHwulZQixQ
𝐒𝐏𝐎𝐍𝐒𝐎𝐑𝐒
• Brex—The modern finance platform, combining the world’s smartest corporate card with integrated expense management, banking, bill pay, & travel. https://brex.com/sourcery
• Turing—Turing delivers top-tier talent, data, and tools to help AI labs improve model performance—and enables enterprises to turn those models into powerful, production-ready systems. https://turing.com/sourcery
• VCX—VCX is the public ticker for private tech, allowing investors of all sizes to invest in venture capital. View The Portfolio at http://GetVCX.com
• Deel—Deel is the global people platform that helps startups hire, manage, pay, and equip anyone, anywhere. Trusted by more than 35,000 fast-growing companies, Deel is the people platform that just works, so teams can scale without the chaos. Visit: https://www.deel.com/sourcery
• Public–Investing platform Public just launched Generated Assets, which lets you turn any idea into an investable index with AI. With Generated Assets, you can build, backtest, refine, and invest in any thesis with AI. Gone are the days of one-size-fits-all ETFs. https://public.com/sourcery
Follow Sourcery for the latest updates!
https://www.sourcery.vc
Disclosure
Paid Endorsement. Brokerage services by Open to the Public Investing Inc, member FINRA & SIPC. Advisory services by Public Advisors LLC, SEC-registered adviser. Crypto trading provided by Zero Hash LLC, licensed by the NYSDFS. Generated Assets is an interactive analysis tool by Public Advisors. Output is for informational purposes only and is not an investment recommendation or advice. See disclosures at public.com/disclosures/ga. Matched funds must remain in your account for at least 5 years. Match rate and other terms are subject to change at any time.
𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒
(00:00) Adam Foroughi, Co-Founder & CEO and Giovanni Ge, CTO at AppLovin
(00:52) Gio's first impression of AppLovin
(03:38) Joining AppLovin after a 30% stock drop
(09:59) How Axon 2 actually got built
(20:23) Why AppLovin never needed a sales team
(21:59) From gaming ads to e-commerce
(24:47) From a napkin drawing to a real product
(30:54) The onboarding mistake most companies make
(34:37) What "AI-Native" actually means
(36:37) Should new engineers still learn to code?
(41:41) UGC vs. traditional ads: what's winning?
(47:56) Adapting to AI without rebuilding from scratch
(54:50) Gio's daily tech stack
(1:02:17) AppLovin's path to a trillion-dollar valuation
(1:06:19) Recovering from a 90% stock drop
(1:09:47) What's next for AppLovin?
(1:13:44) What happens when AI takes over?
(1:15:48) Adam and Gio's hottest takes
(1:19:50) How to actually stay locked in - Sourcery goes inside Neros Technologies’ new 250,000-square-foot Millennium One facility with Co-Founder & CEO Soren Monroe-Anderson.
Neros designed the factory with enough space to eventually produce one million drones per year. Today, the company says it is already manufacturing more than 250 drones per day, with engineering, testing, supply chain and production operating under one roof.
Soren takes us through Neros’ engineering labs, flight-test operation, drone and ground-station assembly lines, manufacturing software and 100% end-of-line flight testing. We also get a look at the latest Bandit interceptor prototype, which can reach roughly 300 km/h, with Neros targeting closer to 400 km/h for intercepting faster jet-powered Shahed variants.
We also visit the new-product introduction line where Neros is preparing Archer AI for mass production, and the massive open portion of the factory reserved for bringing more component manufacturing in-house. Soren explains why mass-producing drones requires designing the product around manufacturing, why 3D printing does not solve the underlying supply-chain problem, and how Neros plans to vertically integrate its way toward million-unit scale.
Soren Monroe-Anderson: https://x.com/soren_ma
Molly O’Shea: https://x.com/MollySOShea
Sourcery: https://x.com/sourceryy
𝐄𝐏𝐈𝐒𝐎𝐃𝐄 𝐋𝐈𝐍𝐊
YouTube: https://youtu.be/1qysc9sNACg
𝐒𝐏𝐎𝐍𝐒𝐎𝐑𝐒
• Brex—The modern finance platform, combining the world’s smartest corporate card with integrated expense management, banking, bill pay, & travel. https://brex.com/sourcery
• Turing—Turing delivers top-tier talent, data, and tools to help AI labs improve model performance—and enables enterprises to turn those models into powerful, production-ready systems. https://turing.com/sourcery
• VCX—VCX is the public ticker for private tech, allowing investors of all sizes to invest in venture capital. View The Portfolio at http://GetVCX.com
• Deel—Deel is the global people platform that helps startups hire, manage, pay, and equip anyone, anywhere. Trusted by more than 35,000 fast-growing companies, Deel is the people platform that just works, so teams can scale without the chaos. Visit: https://www.deel.com/sourcery
• Public–Investing platform Public just launched Generated Assets, which lets you turn any idea into an investable index with AI. With Generated Assets, you can build, backtest, refine, and invest in any thesis with AI. Gone are the days of one-size-fits-all ETFs. https://public.com/sourcery
Follow Sourcery for the latest updates!
https://www.sourcery.vc
Disclosure
Paid Endorsement. Brokerage services by Open to the Public Investing Inc, member FINRA & SIPC. Advisory services by Public Advisors LLC, SEC-registered adviser. Crypto trading provided by Zero Hash LLC, licensed by the NYSDFS. Generated Assets is an interactive analysis tool by Public Advisors. Output is for informational purposes only and is not an investment recommendation or advice. See disclosures at public.com/disclosures/ga. Matched funds must remain in your account for at least 5 years. Match rate and other terms are subject to change at any time.
𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒
(00:00) Inside Neros' 250,000 sq. ft. Millennium One Factory
(01:21) How Neros pushes its drones to the limit
(02:35) Why 3D printing can't solve the drone supply chain problem
(03:40) How their drones are built different
(06:20) The new 300 km/h Bandit interceptor
(09:09) Inside the drone assembly line: producing 250+ drones a day
(11:17) South Bay's biggest American flag
(11:42) How Neros stress-tests its drones
(15:26) Inside the new product introduction line
(17:01) What roles is Neros hiring for
(19:00) Soren's hot take on defense tech - Soren Monroe-Anderson, Co-Founder & CEO of Neros Technologies, joins Sourcery from the company’s new 250,000-square-foot factory in Torrance following its $250 million Series C at a $2.5 billion post-money valuation.
The round, led by Sequoia and American Strategic Technology Fund, comes as Neros expands from its core Archer FPV platform into multiple product lines, including Archer AI and Bandit, its counter-UAS interceptor. Neros is also fresh off a $500 million Army IDIQ and is building toward the capacity to manufacture one million drones annually.
Soren explains why modern warfare is increasingly being shaped by low-cost drones, why America fell so far behind China in drone and electronics manufacturing, and what it actually takes to “de-China-fy” a defense supply chain. Neros has pushed critical components including boards, chips, motors and magnets outside China, but Soren argues complete independence is far harder when Chinese suppliers still dominate some raw materials and precursor chemicals.
We also discuss Neros’ transition from a single-product company to a multi-product defense manufacturer, the rise of interceptor drones, autonomous capabilities that can operate through communications loss, sovereign manufacturing for U.S. allies, and why Soren wants Neros to become the “Toyota of defense manufacturing.”
Soren Monroe-Anderson: https://x.com/soren_ma
Molly O’Shea: https://x.com/MollySOShea
Sourcery: https://x.com/sourceryy
𝐄𝐏𝐈𝐒𝐎𝐃𝐄 𝐋𝐈𝐍𝐊
YouTube: https://youtu.be/a8sFzL-E948
𝐒𝐏𝐎𝐍𝐒𝐎𝐑𝐒
• Brex—The modern finance platform, combining the world’s smartest corporate card with integrated expense management, banking, bill pay, & travel. https://brex.com/sourcery
• Turing—Turing delivers top-tier talent, data, and tools to help AI labs improve model performance—and enables enterprises to turn those models into powerful, production-ready systems. https://turing.com/sourcery
• VCX—VCX is the public ticker for private tech, allowing investors of all sizes to invest in venture capital. View The Portfolio at http://GetVCX.com
• Deel—Deel is the global people platform that helps startups hire, manage, pay, and equip anyone, anywhere. Trusted by more than 35,000 fast-growing companies, Deel is the people platform that just works, so teams can scale without the chaos. Visit: https://www.deel.com/sourcery
• Public–Investing platform Public just launched Generated Assets, which lets you turn any idea into an investable index with AI. With Generated Assets, you can build, backtest, refine, and invest in any thesis with AI. Gone are the days of one-size-fits-all ETFs. https://public.com/sourcery
Follow Sourcery for the latest updates!
https://www.sourcery.vc
Disclosure
Paid Endorsement. Brokerage services by Open to the Public Investing Inc, member FINRA & SIPC. Advisory services by Public Advisors LLC, SEC-registered adviser. Crypto trading provided by Zero Hash LLC, licensed by the NYSDFS. Generated Assets is an interactive analysis tool by Public Advisors. Output is for informational purposes only and is not an investment recommendation or advice. See disclosures at public.com/disclosures/ga. Matched funds must remain in your account for at least 5 years. Match rate and other terms are subject to change at any time.
𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒
(00:00) Soren Monroe-Anderson, Co-Founder & CEO at Neros Technologies
(01:02) Neros just raised $250M at a $2.5B valuation
(04:25) Inside the Army's $500M drone contract
(08:05) The Interceptor drones taking over the battlefield
(12:55) Is it even possible to build a drone without China?
(19:55) The biggest BS claims in defense tech right now
(22:58) Neros’s growth to over 250 employees
(25:29) The Talent bottleneck slowing down American manufacturing
(29:43) The biggest myth about re-industrializing America
(35:52) What actually happens on a modern battlefield?
(37:41) How Starlink is changing drone warfare
(40:41) Soren’s learnings from Kelly Johnson
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