The GLP-1 Podcast Show

In this episode of The GLP-1 Podcast Show, I speak with Dr. Jon Campbell, Associate Professor of Medicine at Duke University, about the changing science of GIP and glucagon. We examine GIP physiology, glucagon signaling, weight-independent metabolic effects, multi-receptor agonism, and variability in treatment response. Discover how emerging pharmacology could shape more precise obesity treatment. Listen now on all major platforms.

"GI think it’s going to take a little while, but people are going to come around to this idea that glucagon, particularly when combined with an incretin like GIP or GLP-1, is a really powerful way to improve metabolic disease."

Meet the guest: Dr. Jon Campbell is an Associate Professor of Medicine at Duke University. His research examines incretin hormones, pancreatic islet biology, and the cellular mechanisms that regulate glucose metabolism. His work has helped advance understanding of GIP, GLP-1, glucagon, and the signaling pathways that may shape future metabolic therapies. Listen to Dr. Jon Campbell on The GLP-1 Podcast Show, available on all major platforms.

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What you will learn:
(00:00) Highlight
(02:11) Introduction
(03:18) GIP biology
(07:13) Hormone contributions
(12:54) Optimized agonists
(16:42) Glucagon actions
(20:30) Multi-hormone therapies
(26:55) Closing thoughts

The GLP-1 Podcast Show is trusted and supported by innovative companies like:

- Zentrix Insights
- ZentrixOS
- WiseVAs
- Elevate

𝗟𝗶𝘀𝘁𝗲𝗻 𝗼𝗻 𝗔𝗽𝗽𝗹𝗲 𝗣𝗼𝗱𝗰𝗮𝘀𝘁𝘀, 𝗦𝗽𝗼𝘁𝗶𝗳𝘆 𝗼𝗿 𝗮𝗻𝘆 𝗺𝗮𝗷𝗼𝗿 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺.
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In this episode of The GLP-1 Podcast Show, I speak with Dr. Ashley Koff, registered dietitian, founder of The Better Nutrition Program, and bestselling author of Your Best Shot, about weight health in the GLP-1 era. She explains why body composition matters more than total weight, how digestion and hydration shape nutrition outcomes, why protein advice must be personalized, and how clinicians can support more sustainable metabolic health. Listen now on all major platforms.

"Weight composition, including the type, amount, and location of bone, muscle, fat, and water, provides a more meaningful signal about health than total weight alone."

Meet the guest: Dr. Ashley Koff is a registered dietitian, founder of The Better Nutrition Program, and bestselling author of Your Best Shot: The Personalized System for Optimal Weight Health. She also serves as Nutrition Course Director for the Integrative and Functional Medicine Fellowship at the Susan Samueli Integrative Health Institute. Her work focuses on personalized nutrition, weight health optimization, metabolic health, practitioner education, and helping patients make better, sustainable choices. Listen to Dr. Ashley Koff on The GLP-1 Podcast Show, available on all major platforms.

Want to stay up to date on the latest GLP-1 research and updates? Subscribe and never miss an episode.

What you will learn:
(00:00) Highlight
(02:07) Introduction
(05:06) Weight health
(07:47) Success markers
(10:07) Tracking trends
(15:31) Functional status
(21:57) Nutrition priorities
(31:43) Future care

The GLP-1 Podcast Show is trusted and supported by innovative companies like:

- WiseVAs
- Elevate
- Zentrix Insights
- ZentrixOS

𝗟𝗶𝘀𝘁𝗲𝗻 𝗼𝗻 𝗔𝗽𝗽𝗹𝗲 𝗣𝗼𝗱𝗰𝗮𝘀𝘁𝘀, 𝗦𝗽𝗼𝘁𝗶𝗳𝘆 𝗼𝗿 𝗮𝗻𝘆 𝗺𝗮𝗷𝗼𝗿 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺.
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In this episode of The GLP-1 Podcast Show, I speak with Dr. Timothy Garvey, Endowed Professor of Medicine at the University of Alabama at Birmingham, about complication-centric care for Adiposity-Based Chronic Disease. We examine current obesity guidelines, medication selection according to complications, what the key unmet clinical need is in obesity care, and the role of second-generation GLP-1 medications in type 2 diabetes. Listen now on all major platforms.

"Obesity treatment should focus on improving complications, quality of life, and health, not simply reaching a target amount of weight loss."

Meet the guest: Dr. Timothy Garvey is Endowed Professor and University Professor of Medicine at the University of Alabama at Birmingham. An endocrinologist specializing in obesity and type 2 diabetes, he has authored more than 380 publications and helped establish Adiposity-Based Chronic Disease as a diagnostic framework while leading major obesity guidelines. Listen to Dr. W. Timothy Garvey on The GLP-1 Podcast Show, available on all major platforms.

Want to stay up to date on the latest GLP-1 research and updates? Subscribe and never miss an episode.

What you will learn:
(00:00) Highlight
(02:14) Introduction
(07:17) Clinical guidelines
(10:35) Complication care
(15:34) Medication selection
(20:39) Disease evidence
(29:40) Diabetes management
(33:22) Closing thoughts

The GLP-1 Podcast Show is trusted and supported by innovative companies like:

- ZentrixOS
- Zentrix Insights
- Elevate
- WiseVAs

𝗟𝗶𝘀𝘁𝗲𝗻 𝗼𝗻 𝗔𝗽𝗽𝗹𝗲 𝗣𝗼𝗱𝗰𝗮𝘀𝘁𝘀, 𝗦𝗽𝗼𝘁𝗶𝗳𝘆 𝗼𝗿 𝗮𝗻𝘆 𝗺𝗮𝗷𝗼𝗿 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺.
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In this episode of The GLP-1 Podcast Show, I speak with Dr. Christopher Kramer, Chief of the Cardiovascular Division at the University of Virginia Health, about how GLP-1 and GIP therapies are reshaping the treatment of obesity-related heart failure. We explore cardiac remodeling, adipose tissue reduction, cardiovascular outcomes, and the mechanisms behind improved patient health. Listen now on all major platforms!

"Treatment with tirzepatide reduced heart failure events by approximately fifty percent while helping patients feel better and perform daily activities more comfortably."

Meet the guest: Dr. Christopher Kramer earned his A.B. from Harvard and his M.D. from UCSF before completing cardiology training at the University of Pennsylvania. He is the George A. Beller, MD/Lantheus Medical Imaging Distinguished Professor of Cardiovascular Medicine and Chief of the Cardiovascular Division at the University of Virginia Health. His research focuses on cardiovascular magnetic resonance imaging and heart disease. Listen to Dr. Christopher Kramer on The GLP-1 Podcast Show, available on all major platforms.

What you will learn:
(00:00) Highlight
(01:40) Introduction
(09:16) Heart failure outcomes
(17:55) Cardiac adipose reduction
(23:01) Ventricular remodeling
(27:42) Weight loss benefits
(30:18) Future triple agonists
(31:36) Final Questions

The GLP-1 Podcast Show is trusted and supported by innovative companies like:

- Elevate
- WiseVAs
- ZentrixOS
- Zentrix Insights

𝗟𝗶𝘀𝘁𝗲𝗻 𝗼𝗻 𝗔𝗽𝗽𝗹𝗲 𝗣𝗼𝗱𝗰𝗮𝘀𝘁𝘀, 𝗦𝗽𝗼𝘁𝗶𝗳𝘆 𝗼𝗿 𝗮𝗻𝘆 𝗺𝗮𝗷𝗼𝗿 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺.
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In this episode of The GLP-1 Podcast Show, I speak with Dr. Richard DiMarchi, Distinguished Professor at Indiana University and a pioneer in peptide therapeutics, about the scientific journey behind GLP-1 therapies, multiagonist drug development, and future obesity treatments. We explore glucagon, GIP, triple agonists, and emerging innovations shaping metabolic medicine. Listen now on all major platforms!

"For decades, glucagon was viewed primarily as a hormone that raises blood glucose. Research later revealed that glucagon could also promote weight reduction and improve liver metabolism when balanced appropriately with GLP-1 activity."

Meet the guest: Dr. Richard DiMarchi is a Distinguished Professor at Indiana University and a recognized leader in peptide therapeutics, diabetes research, and obesity medicine. His work contributed to major advances in insulin, glucagon, and multiagonist therapies, while also helping establish several biotechnology companies. Dr. DiMarchi continues to advance innovation in the treatment of metabolic diseases through research and translational science. Listen to Dr. Richard DiMarchi on The GLP-1 Podcast Show, available on all major platforms.

What you will learn:
(00:00) Highlight
(01:19) Introduction
(05:31) GLP-1 evolution
(09:16) Multiagonist design
(15:46) Glucagon controversy
(17:42) GIP role
(24:32) Future treatments
(30:13) Final Questions

𝗟𝗶𝘀𝘁𝗲𝗻 𝗼𝗻 𝗔𝗽𝗽𝗹𝗲 𝗣𝗼𝗱𝗰𝗮𝘀𝘁𝘀, 𝗦𝗽𝗼𝘁𝗶𝗳𝘆 𝗼𝗿 𝗮𝗻𝘆 𝗺𝗮𝗷𝗼𝗿 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺.
Website: The GLP-1 Podcast Show
Instagram: The GLP-1 Podcast Show
LinkedIn: The GLP-1 Podcast Show
YouTube: The GLP-1 Podcast Show
Facebook: The GLP-1 Podcast Show
TikTok: The GLP-1 Podcast Show