Revolution Health Radio

In this episode of Revolution Health Radio, Chris breaks down a new large-scale study challenging the popular belief that plant-based diets promote longevity. The findings reveal that vegetarians—especially vegans—were significantly less likely to reach age 100 compared to omnivores. Chris explores the biological reasons behind these findings, emphasizing the importance of high-quality protein and nutrient bioavailability, as well as why certain nutrients may be harder to obtain from plant-only diets. He also discusses the powerful nutritional synergy that occurs when plant and animal foods are consumed together, arguing against rigid dietary dogma and advocating for a balanced, omnivorous approach to support healthy aging and longevity.

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In this episode of Revolution Health Radio, Chris sits down with gastroenterologist and microbiome researcher Dr. Zain Kassam to explore the rapidly evolving science of the microbiome and its profound impact on sleep, circadian rhythm, cognitive performance, stress resilience, immune balance, and longevity. From groundbreaking research on microbiome diversity and sleep quality to emerging innovations like cobiotics, Dr. Kassam explains how our microbial partners regulate core biological systems far beyond the gut. They discuss the connection between the gut and the brain, eyes, skin, and even ears—along with practical strategies for supporting microbial health in a modern world that constantly disrupts it.

The post RHR: Beyond the Gut: The Microbiome’s Role in Sleep, Energy, and Longevity, with Dr. Zain Kassam appeared first on Chris Kresser.

Depression and anxiety are often treated as chemical imbalances in the brain—but what if the real problem starts in the gut? In this episode of Revolution Health Radio, we dive deep into the gut–brain connection and the growing body of research linking gut inflammation, microbiome imbalance, and mood disorders. You’ll learn how inflammatory cytokines contribute to depression, why butyrate is emerging as a powerful antidepressant compound, and how specific probiotic strains can improve mental health outcomes. Chris also shares practical, evidence-based strategies—including diet, supplementation, and functional testing—to address root causes and support lasting emotional well-being.

The post RHR: The Gut-Brain Connection: How Your Microbiome Affects Your Mental Health appeared first on Chris Kresser.

In this episode of Revolution Health Radio, Chris Kresser explains why vitamin D supplementation should never be one-size-fits-all. Drawing on new research—including a groundbreaking study on magnesium’s regulatory role—Chris explores how genetics, ethnicity, body weight, age, health status, sun exposure, and nutrient cofactors all shape an individual’s vitamin D needs. He outlines optimal testing strategies, safe and effective target ranges, and the critical roles of magnesium, vitamin K2, and vitamin A in vitamin D metabolism. The episode reframes vitamin D optimization as a personalized, systems-based approach that prioritizes balance, testing, and real-world physiology over generic dosing guidelines.

The post RHR: Vitamin D: Why a Personalized Approach Is Best appeared first on Chris Kresser.

Cold plunges and ice baths dominate social media, but do they really deliver the best metabolic benefits? In this episode of Revolution Health Radio, Chris Kresser challenges the “colder is better” narrative and explores what the science actually shows about cold exposure. Drawing on clinical research, he explains how brown adipose tissue works, why sustained mild cold exposure activates it more effectively than brief extreme cold, and how this can improve insulin sensitivity, glucose metabolism, and overall metabolic health.

The post RHR: Cold Exposure: Why Sustained Beats Extreme appeared first on Chris Kresser.