Thinking In Psychiatry

Access mentioned course here:
Advanced Psychiatric Formulation and Strategic Management Masterclass
https://psychscene.co/3Rn0Sm3 
Here is the link to the paper mentioned:
Towards a Consensus Roadmap for a New Diagnostic Framework for Mental Disorders
https://www.sciencedirect.com/science/article/pii/S0924977X24007168 
In this episode, Dr Sanil Rege examines a 2025 ECNP consensus roadmap calling for psychiatry to move beyond descriptive diagnosis towards biology-informed, transdiagnostic, and mechanism-based models.
He explores how circuit biomarkers, inflammation, genomic overlap, digital phenotyping, and machine learning may refine patient stratification, treatment selection, and relapse prediction across traditional diagnostic boundaries.
This video provides clinicians with a neurobiological framework for shifting from label-based treatment to mechanism-informed formulation in psychiatric practice.

Chapters:
- A Roadmap for Mechanism-Based Psychiatry
- Why Labels Alone are No Longer Enough
- Shared Vulnerabilities Across Diagnostic Boundaries
- Neurocircuit Profiles and Treatment Response
- Inflammation and Targeted Intervention
- Data-Driven Subtypes and Machine Learning
- Biomarker-Enriched Trials and Future Drug Development
- Clinical Pearls for Mechanism-Informed Formulation 
#Psychiatry #DSM5 #ICD11

Access the mentioned paper here:

Trying to Unravel Why Alzheimer Disease Is More Common in Women
By Rita Rubin, MA
https://jamanetwork.com/journals/jama/article-abstract/2839498# 

Access mentioned courses here:
Women’s Mental Health Course:
https://psychscene.co/41RwJx2
Alzheimer’s Disease Course:
https://psychscene.co/4vNaeqH 
In this episode, Dr Sanil Rege examines why Alzheimer’s disease is more common in women and what this means for clinical assessment, prevention, and treatment.

The discussion reviews a 2025 JAMA medical news feature (https://jamanetwork.com/journals/jama/article-abstract/2839498#) on sex differences in Alzheimer’s disease and outlines a life-course model showing how sex-related vulnerability may shape disease onset, progression, and clinical expression.

This video provides clinicians with a sex-informed clinical framework for assessing Alzheimer’s risk in women through the lens of hormonal transitions, cognitive reserve, and later-life neurodegenerative expression.

Chapters:
00:21 Alzheimer’s Disease in Women
02:59 Beyond Longevity
03:40 Survival Differences After Dementia Diagnosis
04:34 Tau Pathology and Steeper Later Decline
06:00 Menopause and Hormonal Vulnerability
08:11 Modifiable Midlife Risk Factors in Women
13:18 A Sex-Informed Life-Course Formulation1

#Alzheimer's #Psychiatry #Dementia

Here are the links to the papers mentioned:
Parkinson’s disease as a somato-cognitive action network disorder
Ren et. al.

https://psychscene.co/4vQKgmc 

The brain’s action-mode network
Dosenbach et. al.

https://psychscene.co/4ts1pRr 
Access mentioned courses here:
Advanced Psychiatric Formulation and Strategic Management:

https://psychscene.co/4sG214L 

ADHD Masterclass:

https://psychscene.co/4sJ1GOS 

In this video, Dr Sanil Rege examines the Action Mode Network as a unifying clinical framework for understanding how the brain regulates action, arousal, body state, and cognition.

He explores the counterbalance between action mode and default mode, showing how impaired initiation, hyperarousal, poor state shifting, and social withdrawal may be better understood as disturbances of mode regulation rather than isolated symptom categories.

This session provides clinicians with a neurobiological framework for refining psychiatric formulation through the lens of state regulation, brain–body integration, and network-based clinical reasoning.

Chapters:
01:32 – Introducing the Action Mode Network
03:17 – The Brain as an Organ Organised for Action
05:48 – Action Mode vs Default Mode
07:18 – Psychiatric Syndromes as Mode-Switching Disorders
09:48– Overcoming the False Dichotomy of Mind and Body
12:25 – The PACES Model in Clinical Formulation
14:48 – Translating State Regulation into Clinical Practice

#ActionModeNetwork #Psychiatry #Brain

Access mentioned courses here:
Advanced Psychiatric Formulation and Strategic Management:

https://psychscene.co/3OGysSJ 
ADHD Masterclass:

https://psychscene.co/3Qd5Sc5 

In this video, Dr Sanil Rege examines the Action Mode Network as a unifying clinical framework for understanding how the brain regulates action, arousal, body state, and cognition.

He explores the counterbalance between action mode and default mode, showing how impaired initiation, hyperarousal, poor state shifting, and social withdrawal may be better understood as disturbances of mode regulation rather than isolated symptom categories.

This session provides clinicians with a neurobiological framework for refining psychiatric formulation through the lens of state regulation, brain–body integration, and network-based clinical reasoning.

Chapters:
01:32 – Introducing the Action Mode Network
03:17 – The Brain as an Organ Organised for Action
05:48 – Action Mode vs Default Mode
07:18 – Psychiatric Syndromes as Mode-Switching Disorders
09:48– Overcoming the False Dichotomy of Mind and Body
12:25 – The PACES Model in Clinical Formulation
14:48 – Translating State Regulation into Clinical Practice
#ActionModeNetwork #Psychiatry #Brain

Access the mentioned courses here:
Sleep And Psychiatry:
 
https://psychscene.co/46d0T09
ADHD and Sleep Dysfunction:
https://psychscene.co/4rrE9Cc
In this episode, Dr Sanil Rege explores the "how and why" of sleep by analysing a 2025 Neuron perspective paper (https://pubmed.ncbi.nlm.nih.gov/40961940/) detailing the interplay between sleep, motor circuits, and catecholamine biology.
The discussion unpacks the motor theory of sleep, in which sleep control is embedded within somatic and autonomic motor circuits, and the catecholamine hypothesis, which posits that a core biological function of sleep is the inactivation of dopamine, noradrenaline, and adrenaline.
This podcast provides clinicians with a neuroscientific framework for understanding sleep as an active state transition involving a global downshift of somatic and autonomic motor systems.
#Sleep #Neuropsychiatry #Insomnia