Buckle up for a trip (pun intended) into the midlife brain. This week we sit down with neuroscientist Dr. Grace Blest-Hopley to connect the dots between cannabinoids, psychedelics, trauma, and the menopause transition. We cover CBD/THC for sleep, anxiety, pain, and inflammation; how the endocannabinoid system works, and how psychedelics like psilocybin act on serotonin pathways, reduce neuroinflammation, and promote neuroplasticity—potentially countering some brain changes seen with estrogen loss. We also dig into trauma (including why PTSD risk and expression differ by sex), the importance of set, setting, and skilled facilitation, who should not use psychedelics, the legal/clinical landscape, and much more. Curious about midlife brain health and whether these therapies are worth exploring? This one’s for you.Dr. Grace Blest-Hopley is a neuroscientist with 12 years experience researching cannabis, cannabinoids, and psychedelics. Grace completed her PhD in Neuroscience at King's College London and currently serves as the Chief Scientific Officer at NWPharma Tech. She is the Research Director at Heroic Hearts Project, a charity that supports combat veterans with mental health challenges resulting from trauma and is also the founder of Hystelica, a community focused on understanding women's biology for safe and effective psychedelic use. In addition to her research and professional roles, she has served as an officer in the British Army Reserve. Dr. Blest-Hopley advocates for the therapeutic potential of these substances and strives to advance the field of psychedelic research. Her work contributes to promoting a better understanding of women's biology in relation to psychedelics. You can learn more about her and her work at hystelica.comSign up for our FREE Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-pageLearn More and Register for our Feisty 40+ Strong Retreat: https://www.womensperformance.com/strongretreat Learn More and Register for our 2026 Tucson Bike Camp: https://www.girlsgonegravel.com/camp Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Phosis: Use the code FEISTY15 for 15% off at https://www.phosis.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% offWahoo KICKR RUN: Use the code FEISTY to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/maTzL This podcast uses the following third-party services for analysis: Spotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Podcorn - https://podcorn.com/privacyPodscribe - https://podscribe.com/privacy
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Breaking the Skinny Spell: Body Image, Building Muscle, and Midlife Resilience with Anne Marie Chaker (Episode 240)
Growing up in sport, this week’s guest was often told her body wasn’t “right”—too muscular, not tall enough, never thin enough—and those messages followed her into adulthood through the pressures of work, marriage, motherhood, and loss. Her turning point came in a hotel gym, where she discovered the power of fueling well, eating enough protein, and lifting heavy. What began as a shift from self-medicating with alcohol to self-empowering with weights eventually led her to bodybuilding, a sport that both celebrates and sometimes complicates women’s bodies. We dig into how eating more can transform health and performance, what it really takes to step on stage, how perimenopause shows up with rage, panic, and fatigue, and why muscle is the “metabolic 401k” every woman needs. This is a conversation about rewriting the script—replacing “small and skinny” with “strong and powerful”—and embracing the bodies we were meant to have. You can learn more about her work at AnneMarieChaker.comAnne Marie Chaker is a veteran journalist and professional bodybuilder. During her two-decade career at The Wall Street Journal, she held reporting jobs all over the paper, from the Journal’s regional editions to the Spot News Desk during the September 11 attack. She has covered everything from politics to news events, consumer trends, education, the workplace, and the major sociological shifts of our time. Chaker lives in the Washington, D.C., area with her partner, Rick; daughters Juliette and Sylvie; and their overeager pup, Ninja. Her latest book is LIFT: How Women Can Reclaim Their Physical Power and Transform Their Lives. Resources:LIFT: How Women Can Reclaim Their Physical Power and Transform Their Lives hereAnne Marie Chaker Substack hereI Never Thought I’d Write This: I Am a Female Bodybuilder, Wall Street Journal I’m 50, in Perimenopause—and About to Compete as a Pro Bodybuilder, Daily BeastSign up for our FREE Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-pageLearn More and Register for our Feisty 40+ Strong Retreat: https://www.womensperformance.com/strongretreat Learn More and Register for our 2026 Tucson Bike Camp: https://www.girlsgonegravel.com/camp Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Phosis: Use the code FEISTY15 for 15% off at https://www.phosis.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% offWahoo KICKR RUN: Use the code FEISTY to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/maTzL This podcast uses the following third-party services for analysis: Spotify Ad Analytics -...
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You're Never Too Old to Be Young Again: Chasing 100 Miles at Age 65 with Diane Grim (Episode 239)
At 65, Diane Grim was the oldest woman competing at the Western States 100–widely considered one of the toughest organized trail runs in the United States–this year. It was her first ever 100 miler and she didn’t even start running till she was in her 50s, but as she says, every mile, every step is a gift, so why not? She didn’t have the day she hoped for, but she left filled with pride, hope of better days to come, and a newfound goal to wrap up some unfinished business. This week she shares her successes, failures, her crazy training days during menopause, and why you’re never too old to be young again. Diane is a former bike racer turned trail runner at age 50, and she hasn’t literally or figuratively backpedaled since! Diane’s trail friends call her “MacGyver” thanks to her love of problem-solving and making things on the fly. She runs by the motto: If you can’t run fast, run smart. Every mile is a gift! Anywhere outside is Diane’s happy place and you can find her hammock camping, landscaping, building stuff or running through the woods like a kid! Diane is so grateful to be running Western States, proudly sponsored by the HOKA Outreach Program.Resources:https://www.instagram.com/p/DLYYfiPPtw0/https://trailsisters.net/women-of-wser/#:~:text=the%20Panelists%20%26%20Host-,Diane%20Grim,t%20run%20fast%2C%20run%20smart.Sign up for our FREE Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-pageLearn More and Register for our Feisty 40+ Strong Retreat: https://www.womensperformance.com/strongretreat Learn More and Register for our 2026 Tucson Bike Camp: https://www.girlsgonegravel.com/camp Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Phosis: Use the code FEISTY15 for 15% off at https://www.phosis.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% offWahoo KICKR RUN: Use the code FEISTY to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/maTzL This podcast uses the following third-party services for analysis: Spotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Podcorn - https://podcorn.com/privacyPodscribe - https://podscribe.com/privacy
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Own Your Mountain: Menopause, Resilience & Summiting Mount Everest with Jeannette McGill (Episode 238)
She did it. At 10:06 a.m. on May 24th, two-time guest Jeannette McGill stood on top of the world. Jeannette, 52, summited Mount Everest after three years of navigating hot flashes, heavy, erratic periods, joint pain, stubborn injuries, brain fog, and maybe most difficult of all for a high altitude mountaineer–newfound fear that made tasks that once came easily feel overwhelming. Along the way, including two abandoned summit attempts, Jeannette learned that through the power and support of community and with patience, persistence, and practice you can get through even the darkest of tunnels to reach your goals. She shares her journey and the wisdom learned along the way this week.Jeannette McGill is the first South African woman to summit Manaslu and the first-ever South African to climb Dhaulagiri - two of the 14 8,000-meter (26,000 feet) mountains in the world. She is passionate about supporting others to achieve their outdoor goals through her mountain mentoring and leads bespoke adventures in the Australian Alps and Nepal. Her portfolio career also includes industrial technology management, and she has a PhD from the Colorado School of Mines. You can learn more about her and her work as a mentor and guide at www.mcgillsmountains.com/ResourcesMenopause Lessons from the Mountains with Jeannette McGill (Episode 89)Fear and the Quest for Everest in Menopause with Jeannette McGill (Episode 195)Sign up for our FREE Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-pageLearn More and Register for our Feisty 40+ Strong Retreat: https://www.womensperformance.com/strongretreat Learn More and Register for our 2026 Tucson Bike Camp: https://www.girlsgonegravel.com/camp Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Phosis: Use the code FEISTY15 for 15% off at https://www.phosis.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% offWahoo KICKR RUN: Use the code FEISTY to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/maTzL This podcast uses the following third-party services for analysis: Spotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Podcorn - https://podcorn.com/privacyPodscribe - https://podscribe.com/privacy
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Why the Calories In/Calories Out Equation Can Fail Women with Jody Dushay, MD (Episode 237)
How many times have we heard that weight loss and maintenance is simply “calories in, calories out?” Well, the equation may be rooted in thermodynamics, but the reality is biology, history, hormones, and a whole lot more. This week, endocrinologist and Harvard obesity researcher Dr. Jody Dushay breaks down why this concept is far more complex than the numbers on a food label or how many calories our devices tell us we’ve burned. From how your body actually absorbs calories to how (or not) it expends them, we explore how and why weight gain and loss anything but straightforward—especially during menopause, when shifting body composition, gut microbiome changes, altered insulin responses, and evolving hormone levels, create a whole new metabolic landscape. As you’ll see, your body isn’t a calculator—it’s a dynamic, adapting system. We also revisit GLP-1 drugs, which are increasingly popular with midlife women, and where they fit in this whole equation (so to speak). Jody Dushay, MD, MMSc, is an endocrinologist at the Beth Israel Deaconess Medical Center and assistant professor of medicine at Harvard Medical School. She is also the founder and director of Well Powered, a comprehensive wellness and weight management program. Dr Dushay has studied the effect of pharmacotherapies and dietary interventions on body weight for years, including a large single-site study examining the effects of a glucagon-like peptide receptor agonist on body weight in obese women without diabetes. As a triathlete, she has qualified for Kona 3 times and came in 2nd in her age group at the 2020 Ironman World Championship in St George. You can learn more about her and her work at wellpowered.org.Resources:Dr. Jody Dushay’s research:Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetesWeight Loss Outcomes Among Early High Responders to Exenatide Treatment: A Randomized, Placebo Controlled Study in Overweight and Obese WomenSign up for our FREE Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-pageLearn More and Register for our Feisty 40+ Strong Retreat: https://www.womensperformance.com/strongretreat Learn More and Register for our 2026 Tucson Bike Camp: https://www.girlsgonegravel.com/camp Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Phosis: Use the code FEISTY15 for 15% off at https://www.phosis.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% offWahoo KICKR RUN: Use the code FEISTY to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/maTzL This podcast uses the following third-party services for analysis: Spotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Podcorn - https://podcorn.com/privacyPodscribe - https://podscribe.com/privacy
Perimenopause and menopause hit active women differently. We have a different lifestyle and different goals. And we know our bodies. Whether you run and hike or do CrossFit and ski (or a little of everything!), you’ve had a way of eating and exercising that worked…until the menopause transition, when it all goes out the window as body composition changes, fatigue, body aches, sleepless nights, hot flashes, brain fog, mood swings, and low mojo blindside you out of the blue—despite doing everything right. Your doctor may (or may not) help with hormone replacement therapy. But what about all the active stuff you love? You’re already exercising and eating well. What you want is to feel and perform like you used to. That doesn’t mean fasting, swearing off carbs for life, or just slowing down. It means adjusting your nutrition, training, recovery, and mindset to work with your changing physiology as you hit this phase of life. And we’re here for it.
At Hit Play Not Pause, we know the potential of women in their 40s, 50s, 60s, and beyond, because we talk to elite athletes and everyday active women who are still hitting personal bests along with world-renowned sports dietitians, researchers, medical and menopause specialists to help you understand what’s happening under the hood during the menopause transition and more importantly, what you can do about it—from hormone therapy to heavy lifting and everything in between—to feel and perform your best.
Host Selene Yeager is a health and science journalist with 30 years’ experience and more than two dozen books to her name. She also lives an active life as a former Ironman triathlete and professional mountain bike racer who still rides, runs, paddles, hikes, lifts, and through her work at Feisty Menopause helps others do the same.
This podcast uses the following third-party services for analysis:
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