JAMA Clinical Reviews

POTS is a chronic autonomic disorder characterized by excessive orthostatic tachycardia and multisystem symptoms that affects an estimated 0.1% to 1% of the US population. Author Satish Raj, MD, MSCI, of University of Calgary Cumming School of Medicine joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss current evidence about the pathophysiology, diagnosis, and management of POTS.

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Postural Orthostatic Tachycardia Syndrome (POTS)

Naltrexone, acamprosate, disulfiram, and topiramate are effective but underused medications for treatment of alcohol use disorder. Author Stephen Holt, MD, MS, of Yale School of Medicine joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss first-line pharmacotherapy for alcohol use disorder and important safety, efficacy, and hospital initiation considerations.

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Medications for Alcohol Use Disorder

Circulating tumor DNA (ctDNA)(liquid biopsies) can help monitor cancer progression, detect residual cancer after treatment, and identify genetic changes within cancer cells that could affect treatment response. Author Ben Ho Park, MD, PhD, of the Vanderbilt-Ingram Cancer Center discusses current evidence regarding use of liquid biopsies in management of cancer with JAMA Deputy Editor Mary McGrae McDermott, MD.

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Applications of Liquid Biopsy for Surgical Patients With Cancer

Physical activity is an effective component of care for people with chronic medical conditions. In this podcast, JAMA Insights author Alessio Bricca, PhD, University of Southern Denmark, discusses adaptable methods to promote physical activity in patients with chronic medical conditions with host Anne Rentoumis Cappola, MD, ScM.

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Communicating With Patients About Physical Activity

Hodgkin lymphoma is a relatively rare disease, with approximately 82 409 incident cases reported globally in 2022, and 8720 cases reported in the US in 2025. Author Alison Moskowitz, MD, of Memorial Sloan Kettering Cancer Center joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss current evidence about the diagnosis and management of Hodgkin lymphoma in adults.

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Classic Hodgkin Lymphoma