The Great Simplification with Nate Hagens

The number of couples struggling to become pregnant due to unexplained infertility is growing at an alarming rate across the globe. Alongside this concerning rise is the growing awareness of how endocrine disrupting chemicals (EDCs) – particularly those found in plastics and personal care products – are negatively affecting our hormonal health and overall well-being. If we removed or reduced EDCs from the environments of couples struggling to conceive – dramatically reducing their exposure – is it possible their fertility would be improved? 
In this episode, Nate is joined by Dr. Shanna Swan, an award-winning scientist, and Sian Sutherland, a plastics expert, to discuss Shanna's new Netflix documentary, titled The Plastic Detox, where she enacts a real-world 'plastic intervention' in the lives of six couples struggling with unexplained infertility – with the hope that they are able to get pregnant by the end of the study. Additionally, Sian shares the strategies her organization has been using to increase regulation of EDC-containing products and increase the availability of plastic-free options. Shanna and Sian also discuss how they're bringing their work together for the Plastic Free Babies campaign, which emphasizes why avoiding toxic chemical exposure during the first one-thousand days of a baby's life is so important to preventing generational effects on overall health and fertility. 
How might reducing our exposure to EDCs such as phthalates, bisphenols, and parabens improve markers of hormonal health and create ripple effects on our overall quality of life? What is the reasonable responsibility of our governments to test and regulate the safety of products on the market – and are our current institutions fulfilling those expectations? Finally, could addressing the toxins and pollution related to declining fertility lead us down a path of broader systemic change for the entire web of life? 
 
About Dr. Shanna Swan:
Dr. Shanna H. Swan, PhD, is an award-winning scientist based at Mt. Sinai (New York, NY). Shanna has published more than 200 scientific papers and has been featured in extensive media coverage around the world. She currently serves as the Director of the Action Science Initiative, a program that conducts rapid interventions and larger, longer-term studies that look at the impacts of environmental pollutants on fertility and related markers of reproductive health. Additionally, Shanna co-authored the 2021 book, Countdown: How Our Modern World Is Threatening Sperm Counts, Altering Male and Female Reproductive Development, and Imperiling the Future of the Human Race. 
Most recently, Shanna was featured in the documentary, The Plastic Detox, where she helped six couples dealing with unexplained fertility reduce their exposure to endocrine disrupting chemicals in their environment in hopes of getting pregnant. The movie was released on Netflix on March 16th, 2026. Shanna's previous appearances include ABC News, NBC Nightly News, 60 Minutes, CBS News, PBS, BBC, PRI Radio, NPR, Andrew Huberman Lab, and The Joe Rogan Experience. 
 
About Sian Sutherland:
Sian Sutherland is Co-founder of A Plastic Planet, one of the most recognized and respected organizations tackling the plastic crisis. More recently, she also co-founded PlasticFree, the first materials and systems solutions platform, empowering the 160m global creatives to design waste out at the source. Sian was awarded the Female Marketer of the Year, Entrepreneur of the Year, and British Inventor of the Year. In 2023 at the UN Plastics Treaty negotiations (INC2), in partnership with Plastic Soup Foundation, A Plastic Planet launched the Plastic Health Council, bringing expert scientists to the negotiating process with the irrefutable proof of plastic chemicals' impacts on human health. 
Most recently, in early 2024, Sian co-founded the Foundation for Visionary Science and Art with Alex Adams, working with the scientists to help fund their extraordinary research work on psychedelic therapies. Passionately pro-business and solutions focused, Sian believes the plastic crisis gives mankind a rare gateway to change both materials and systems to create a different future for next generations.
 
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This week's Frankly marks the second installment of Nate's recurring series, Uncomfortable Questions in Unsettled Times, where he poses questions about our shared future. While the first edition posed broad questions about civilizational trajectory, today's episode is prompted by the Iran situation and what happens when geopolitics stops feeling distant and starts arriving as supply chain disruptions, rising prices, fear, and renewed stories about enemies and allies.
Nate walks through five questions that move from the practical to the interior. He begins with the gap between what is essential and what is merely familiar in modern life, asking listeners to identify what they depend on before scarcity makes the choice for them. From there, Nate turns inward to examine what the act of assigning blame actually does to our nervous systems and our capacity for response, and poses a larger geopolitical question about whether the collapse of U.S. global power would be net positive or net negative for the world. He then asks listeners to imagine their own town or community in 2050, and what actions they might take now with a few people around them. The episode closes with a reflection on fear as a force that narrows perception and collapses the potential for action, drawing on Frank Herbert's Dune and Nate's own honest response to watching a scenario he had long gamed out begin to move closer to reality.
What fears about the future are quietly limiting your ability to act today, and which are actually helping you prepare? Is assigning blame increasing your capacity for meaningful action, or mostly giving shape to your distress? And if your future is going to become more local than you expect, what could you begin to do now with a few people in order to move toward the better end of the distribution?
(Recorded March 11th, 2026)
 
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Nearly every mainstream conversation about humanity's future, our current global crises, and our place in the natural world shares one common theme: the quiet, unquestioned assumption that humans are the apex species on Earth. This belief is so woven into our systems and thought patterns that it rarely gets named, let alone challenged. But what if this invisible worldview – more than fossil fuels, overpopulation, or any single policy failure – is at the very root of the ecological crisis?
In this episode, Nate speaks with primatologist and author Dr. Christine Webb about human exceptionalism – the deeply embedded belief that humans are separate from and superior to the rest of nature. Webb argues this worldview is not a universal human trait but rather a product of a few dominant cultures, and that it lies at the root of many of our most pressing global challenges. Drawing on her research with chimpanzees, bonobos, baboons, and other non-human primates, she illustrates how traits once thought to be uniquely human (like tool use, language, empathy, theory of mind, and culture) are in fact shared across species in various forms. Furthermore, Webb advocates for reimagining economic, legal, and educational systems to reflect the intrinsic value of all life.
What, exactly, is the meaningful line between "us" (humans) and "them" (other species), and who benefits from drawing it? How are current scientific 'best practices' accidentally reinforcing the myth of human exceptionalism, and what can we do to change them? And finally, if we decenter human exceptionalism, what richness might we stand to gain in community, meaning, and wellbeing?

(Conversation recorded on February 17th, 2025) 
 
About Christine Webb:
Dr. Christine Webb is a primatologist and Assistant Professor in the Department of Environmental Studies at New York University as a part of the Animal Studies program. Prior to joining NYU, she was a Researcher and Lecturer in the Department of Human Evolutionary Biology at Harvard University.
Her research follows two intersecting lines of inquiry: understanding the complex dynamics of social life in animals, especially other primates, and examining how the dominant narrative of human exceptionalism has shaped scientific knowledge of the more-than-human world. These two lines of research have cumulated into her 2025 book, The Arrogant Ape: The Myth of Human Exceptionalism and Why It Matters, which argues that human exceptionalism is an ideology that relies more on human culture than our biology, and more on delusion and faith than on evidence.


 
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This week's Frankly is another edition of Nate's Wide Boundary News series, where he invites listeners to view the constant churn of headlines through a wider-boundary lens. In this installment, Nate addresses the U.S. and Israeli military offensive against Iran and traces the reverberating effects that extend far beyond the conflict itself, starting with what the closure of the Strait of Hormuz means for a civilization that routes a massive share of its physical economy through a single maritime corridor.
Nate begins with the core misperception that oil registers as roughly 3% of GDP by cost, when in reality it underpins 100% of economic activity. Building off of that, he outlines a series of second- and third-order effects that rarely appear in headline coverage, including hidden dependencies on sulfur, liquefied natural gas, and nitrogen fertilizer that connect the Strait of Hormuz to mining operations, European energy security, and global food systems. He also explains the stock-and-flow imbalance between expensive missile interceptors and cheap drone warfare, and the difficult choices facing aging Middle Eastern oil fields if production is forced to shut in. Finally, Nate considers the religious narratives on all three sides of the conflict, where Christian, Jewish, and Shia Islamic end-times frameworks each cast the war as prophetic fulfillment, short-circuiting the feedback loops that normally slow escalation.
What does the exposure of a single shipping corridor reveal about the deep energy dependencies of modern civilization? How might the second- and third-order effects of this conflict, from fertilizer to metals to food prices, reshape the global economy in ways that outlast the war itself? And when all parties in a conflict believe they are fulfilling divine prophecy, where do the off-ramps for de-escalation appear?
(Recorded March 9th, 2026)
 
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In this week's Frankly, Nate begins a new series called "Staying Human," which focuses on what he sees as a precondition for everything else: recovering a sense of personal agency. He opens against the backdrop of Operation Epic Fury and the broader turbulence of 2026, but rather than offering geopolitical analysis, he turns inward toward a question that has been reshaping his theory of change: why does growing awareness of the more-than-human predicament so often produce paralysis rather than action?
Nate traces the gap between awareness and agency through several layers. He draws on the science of learned helplessness and self-efficacy research to explain how nervous systems learn whether effort leads to outcomes, and how a digital environment designed to fragment attention can train people to stop investing in their own follow-through. He frames this not as a personal failing but as a predictable consequence of living inside a Superorganism that advertises choice while eroding the conditions for it. Rather than prescribing a program, Nate shares practices he is experimenting with himself: voluntary speed bumps before reaching for a screen, small kept promises that rebuild self-trust, and protecting even one hour of intentional time. He argues that reclaiming agency at the individual level is not sufficient to address our entire predicament, but it is a precondition for the community-level and institutional work required to make the future better than the default.
Where in your life has awareness of the world's problems triggered overwhelm or even paralysis? What is one kept promise, however small, that might begin to rebuild your sense of traction? And if agency is a precondition for everything that comes next, what would it look like to treat it as something you practice rather than something you wait to feel?
 
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