This Week in Cardiology

Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
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DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588
II Another Failure of Posterior Wall Isolation
CORNERSTONE-AF Trial https://doi.org/10.1093/eurheartj/ehag486
CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186
PVIOTAL IDE Trial 10.1016/j.hrthm.2025.08.018 External Link
III First Line AF ablation – One new study and a discovery about a second one
Catheter Ablation vs AAD for First-line Treatment of AF 10.1016/j.hrthm.2025.07.061 External Link
EAST-AFNET 4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2019422
Cardiology Trials Substack https://cardiologytrials.substack.com/p/summary-and-discussion-of-east-afnet
IV Left Atrial Appendage Closure Meta-analysis
Long-Term Efficacy and Safety of LAAC vs OAC -- Meta-analysis https://academic.oup.com/europace/article/28/7/euag159/8739567
V Prevention of AKI after Cardiac Surgery: MERCURI-2
MERCURI-2 Study https://jamanetwork.com/journals/jama/fullarticle/2852324
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic injuries in cardiology are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
 
I Enlicitide Approved
First Oral PCSK9 Inhibitor Welcomed for Potential Primary Care Impact https://www.medscape.com/viewarticle/first-oral-pcsk9-inhibitor-welcomed-potential-primary-care-2026a1000own
Dr Gregory Katz Substack https://gregorykatz.substack.com/p/are-we-sure-mercks-new-cholesterol
CORALreef Lipids Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002
CORALreef HeFH Trial https://jamanetwork.com/journals/jama/fullarticle/2841258
CORALreef Outcomes Trial https://clinicaltrials.gov/study/NCT06008756
II MRI Scans in Non-conditional CIEDs
Specialized Nurse Practitioners Safely Manage MRI in Patients With Cardiac Implantable Devices https://www.medscape.com/viewarticle/specialized-nurse-practitioners-safely-manage-mri-patients-2026a1000ozt
Nurse Practitioner-Led CIED Monitoring During MRI 10.1016/j.hroo.2026.04.031 External Link
MRI in Nonconditional Pacemakers and ICDs https://academic.oup.com/europace/article/22/2/288/5717383
Heart Rhythm Society Consensus Document 10.1016/j.hrthm.2017.04.025 External Link
III PFA-SHAM trial
PFA-SHAM Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484
SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283
IV Orthopedic Injuries in Cardiology
What Will It Take to Make Fluoroscopy Labs Safer?
https://www.medscape.com/viewarticle/what-will-it-take-make-fluoroscopy-labs-safer-2026a1000ox6
Expert Consensus Statement on Enhanced Radiation Protection https://www.jacc.org/doi/10.1016/j.jcin.2026.06.011
'Shed the Lead' and the Injuries. Should Cath Labs Go Lead-Free? https://www.medscape.com/viewarticle/shed-lead-and-injuries-should-cath-labs-go-lead-free-2024a1000hnb
Health Hazards of Working in the Interventional Laboratory https://doi.org/10.1016/j.jacc.2014.11.056
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

DAPT back in the news, a practice-changing trial in VTE therapy, new knowledge in sudden cardiac death, heart failure definitions updated, and a dumb decision by NICE in the UK are the topics discussed by John Mandrola, MD, in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Antiplatelet Therapy After Stenting
DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588
HOST-EXAM Trial at 2 years https://pubmed.ncbi.nlm.nih.gov/34010616/
HOST-EXAM Trial at 10 years 10.1016/S0140-6736(26)00422-8 External Link
Nick Kurzen on X https://x.com/ncurzen/status/2077676739463922151
II Aspirin Proves Its Mettle After Hip and Knee Replacement
EPCAT III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2603649
CRISTAL Trial https://jamanetwork.com/journals/jama/fullarticle/2795528
III New (and old) Knowledge in Sudden Cardiac Death
Sudden Cardiac Death and its Relation to Cardiac Disease at Autopsy https://doi.org/10.1016/j.jacc.2026.01.029
Sudden Cardiac Death Due to MI With Obstructive and Nonobstructive Coronary Arteries https://doi.org/10.1016/j.jacc.2026.01.030
Frequency of Sudden Cardiac Death and Profiles of Risk https://www.ajconline.org/article/S0002-9149(97)00477-3/fulltext
IV Heart Failure Diagnosis
AHA/ACC/ESC/WHF Expert Consensus Document http://jacc.org/doi/10.1016/j.jacc.2026.05.036
V NICE Makes a Dumb Decision
NICE Recommends New Nonsteroidal MRA for Heart Failure
https://www.medscape.com/viewarticle/nice-recommends-new-nonsteroidal-mra-heart-failure-2026a1000nzv
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

Listener feedback on ICE vs TEE in AF ablation, fractional flow reserve without a wire or catheter, more bad news for ticagrelor, the POLY-HF trial, and oxygen targets after cardiac arrest are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Oct 10, 2025 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1002990
ICE vs TEE in Atrial Fibrillation Ablation https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370
II FFR Without the Wire – Angiography-Derived FFR to Guide PCI
ALL-RISE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600949
FAST III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601841
FAVOR III Trial 10.1016/S0140-6736(24)02175-5 External Link
FAME 2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1205361
 
Venk Murthy on X https://x.com/venkmurthy/status/2074849421452329456?s=20
III More Bad News for Ticagrelor
Jul 11, 2025 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1002704
Prasugel, Ticagrelor, or Clopidogrel After PCI https://jamanetwork.com/journals/jamacardiology/fullarticle/2849614
IV The Polypill in Heart Failure
POLY-HF trial https://www.nature.com/articles/s41591-026-04504-5
V Oxygen Targets After Cardiac Arrest
LOGICAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513814
ICU-ROX Trial https://link.springer.com/article/10.1007/s00134-020-06196-y
Secondary Analysis of the PILOT Trial https://journal.chestnet.org/article/S0012-3692(25)00553-7/fulltext
Oxygen Targets in Comatose Survivors of Cardiac Arrest https://www.nejm.org/doi/10.1056/NEJMoa2208686
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

Listener feedback on valvular heart disease, statins and frailty, left atrial posterior wall ablation fails again, interpreting medical tests and AI ECG reading are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137
II Statins and Frailty
Statin Initiation Tied to Lower Frailty Risk in Older Adults https://www.medscape.com/viewarticle/statin-initiation-tied-lower-frailty-risk-older-adults-2026a1000lec
Statins and Survival Free of Incident Frailty  https://doi.org/10.1093/eurheartj/ehag451
III LA Posterior Wall Isolation Fails Again
CORNERSTONE Trial https://doi.org/10.1093/eurheartj/ehag486
CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186
IV Does the Display of Test Results Improve Clinical Decisions?
Interval Likelihood Ratios for Clinical Decsion-Making https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500249
Making Sense of Health Statistics https://journals.sagepub.com/doi/full/10.1111/j.1539-6053.2008.00033.x
V AI and the ECG and Saving Doctors
Case Report — AI-Enhanced Diagnostics https://www.nature.com/articles/s41591-026-04454-y
The New York Times article https://www.nytimes.com/2026/06/22/health/artificial-intelligence-heart-damage.html
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net