This Week in Cardiology

Listener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
POET II Response-Tailored or Standard-Duration ABX for Infectious Endocarditis
POET I Trial https://www.nejm.org/doi/10.1056/NEJMoa1808312
POET II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607887
II PVI-SHAM-AF trial Back in the News
GAP-AF Trial https://www.ahajournals.org/doi/10.1161/circep.115.003337
PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link
Why Sham Studies Are a Sham in 2026 10.1016/j.hrthm.2026.09.056 External Link
The Indispensable Role of Sham Controls in Evaluating Interventional Therapies 10.1016/j.hrthm.2026.10.001 External Link
III ICDs in HCM
I CDs for the Prevention of SCD in High-Risk Patients with HCM https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.078597
ICDs in HCM: Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079687
IV Agenda Laundering
How Commercial “Agenda Laundering” Shapes Critical Care https://www.bmj.com/content/395/bmj-2026-100963
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

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Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7
Identifying LV Posterior Wall Delay in RBBB Using Lead V8 https://doi.org/10.1016/j.jacep.2026.03.009
Using Lead V8 as a Tool to Improve Patient Selection in CRT https://doi.org/10.1093/europace/euaf194
II POET II Response-Tailored or Standard-Duration Antibiotics for Endocarditis
POET I https://www.nejm.org/doi/10.1056/NEJMoa1808312
POET II https://www.nejm.org/doi/full/10.1056/NEJMoa2607887
III Obesity and AF – A Neat Study from the Team in Prague
LA Remodeling and Functional Maladaptations in Obesity https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014509
IV Reducing CAC: The DANCODE Trial
DANCODE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.082363
V Two Big RCTs of New GLP-1 Drugs
TRIUMPH-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2604169
SYNCHRONIZE-2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607219
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

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Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback LBBP ICD Lead
LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/
TRIC-I-HF trial
TRIC-I-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
Growth of Tricuspid Interventions in Germany https://www.jacc.org/doi/10.1016/j.jcin.2025.05.030
II Treatment of Acute Intermediate-High Risk PE – the PRAGUE-26 Trial
PRAGUE-26 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608012
III Targeting CS leads in CRT devices – DANISH-CRT Trial
DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7
IV Exercise for AF, Especially When There Is LA Disease
Physical Activity and Risk of Incident AF in Atrial Cardiomyopathy https://www.jacc.org/doi/10.1016/j.jacadv.2026.102999
V Paradoxical Low-Flow, Low-Gradient AS – REBOOT-PARADOX
REBOOT-PARADOX trial 10.1016/j.jacc.2026.08.017
ROTAS Trial https://heart.bmj.com/content/110/20/1223
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

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Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Correction on PROFID Trial
II Listener Feedback
III Fifth Universal Definition of MI
Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101
Foy/Mandrola Editorial on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967
IV New ESC HF Guidelines
ESC Guidelines for Management of HF https://doi.org/10.1093/eurheartj/ehag100
Sanjay Kaul on X https://x.com/kaulcsmc/status/2094959683215958158?s=20
Geographic Disparities in TOPCAT https://pmc.ncbi.nlm.nih.gov/articles/PMC5065247/
V AIR STEMI Trial
AIR-STEMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605373
CR Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051
PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
VI GLP-1 News – A SELECT Trial Secondary Analysis
Semaglutide and hsCRP in Patients with CVD and Obesity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.074482
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

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A second ESC recap plus two breaking stories on the failure of an investigational Lp(a) reducing drug and a new FDA approval of an AI-ECG app are covered by John Mandrola, MD
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Lp(a) Disappointment
HORIZON https://clinicaltrials.gov/study/NCT04023552
Press Release https://www.novartis.com/news/media-releases/novartis-announces-lpahorizon-phase-iii-topline-results-pelacarsen-patients-elevated-lpa-and-established-cardiovascular-disease-cvd
Rationale paper https://doi.org/10.1016/j.ahj.2025.03.019
II FDA Clears AI-ECG for Acute MI Detection
Accuracy of cath lab activation decisions for STEMI-equivalent and mimic ECGs: Physicians vs. AI (Queen of Hearts by PMcardio) 10.1016/j.ajem.2025.07.061
AI-Enabled ECG Analysis Improves Diagnostic Accuracy and Reduces False STEMI Activations: A Multicenter U.S. Registry https://www.jacc.org/doi/10.1016/j.jcin.2025.10.018
Queen of Hearts™ AI ECG App https://www.powerfulmedical.com/pmcardio-stemi/
III TARGET CTCA Trial
Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain https://www.nejm.org/doi/10.1056/NEJMoa2608903
IV CorCal trial
Press release https://www.escardio.org/news/press/press-releases/new-data-presented-on-the-use-of-coronary-artery-calcium-for-cardiovascular-risk-assessment/
CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design and baseline characteristics https://doi.org/10.1016/j.ahj.2026.107473
V AMUNDSEN Trial
LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial InfarctionThe AMUNDSEN Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2853274
VI TRIC-I-HF trial
Tricuspid Repair Cuts Death, HF Hospitalization in Severe TR https://www.medscape.com/viewarticle/tricuspid-repair-cuts-death-hf-hospitalization-severe-tr-2026a1000wvk
Tricuspid-Valve Intervention in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

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