Possible

In this special episode of Reid Riffs, Reid and Aria are joined by Pulitzer Prize–winning author, oncologist, and Manas AI cofounder Siddhartha Mukherjee for a few questions about cancer, AI, and the second edition of The Emperor of All Maladies. Reflecting back on the 15 years since its initial publication, Reid, Aria and Sid discuss how cancer prevention, early detection, and immunotherapy have fundamentally shifted while the disease continues to be a defining challenge of modern medicine. The conversation charts how AI can become a true engine of drug discovery and how Manas was built to be an AI-native biopharmaceutical company focused on developing entirely new medicines. The episode then broadens out to tackle the current cultural moment in Silicon Valley, questioning whether the Valley is entering a new Renaissance driven by more meaningful work, clearer values, and a renewed theory of human progress. The episode closes by grappling with AI’s growing persuasive power in politics and public discourse, and the responsibility to design systems that elevate truth, agency, and humanity rather than distort them.

In this episode of Reid Riffs, Reid and Aria explain why "compute" is the new oil powering the cognitive industrial revolution. They argue that the United States must urgently expand domestic data centers and energy infrastructure to remain globally competitive. The conversation explores how rapid data center construction is transforming blue-collar labor markets, driving significant wage growth for electricians, HVAC technicians, and skilled trades while dispelling misinformation about data centers' impact on rising electricity costs. Reid warns that China's aggressive energy expansion is also widening the global competitiveness gap, underscoring the need for stable, long-term U.S. energy policy spanning nuclear, natural gas, solar, and wind. Reid and Aria also discuss how America's next era of prosperity hinges on how decisively it builds the physical backbone of AI and why keeping AI infrastructure on U.S. soil is critical for jobs, intellectual property, and national security.

In this special live episode of Possible, Reid and Aria sit down with Wispr Flow founder and CEO Tanay Kothari to explore a post-keyboard future where voice becomes the primary way humans interact with computers. From building one of the world’s first voice assistants as a child to creating a product now used the world over (with, as of publish, 70% user retention after one year and daily users at over half of the Fortune 500), Tanay shares how Wispr Flow removes the cognitive friction of typing and restores natural communication to our digital world. The conversation touches on increasing accessibility to AI, emotional tone in digital communication, and why speaking to computers may ultimately be more human than typing ever was. And shortly into the conversation, Tanay puts his tech to the test in a live demo that pits a 110-words-per-minute typist against Wispr Flow in a dramatic battle of speed and accuracy. This episode showcases what is possible in a future where technology fades into the background and nudges people to become more present in the real world. A big thanks to Sean Mendy and the Westbound Equity Partners, and David Stiepleman and the Sixth Street Partners for hosting the conversation. And a shout to Isabella Sikaffy and the Florabella Studios team, Marshall Potter and the Push Record team, and Marcus Chua and the Wispr Flow team.

This week, Reid and Aria dive into three central AI stories that have been dominating the headlines: Pope Leo XIV issues a powerful call for moral discernment in an AI-driven world, Anthropic reveals that state-sponsored hackers used agentic AI to automate a sophisticated cyberattack, and Disney considers a radical shift as it weighs opening its IP vault to fan creators. Reid reflects on what it means when spiritual, civic, and technological institutions all step into the AI conversation and how the race between offensive and defensive AI will define the next era of security. Reid and Aria also break down what Disney's creative signals mean for IP ownership, storytelling, and the relationship between mega-studios and their audiences. The overarching question that runs through this episode: how does society stay anchored in human dignity as AI reshapes everything from faith to culture?

Software is eating the world, but will it start eating us? On this episode of Possible, Aria Finger and Reid Hoffman sit down for an encore conversation with Aza Raskin that dives deep into how AI and engagement-driven tech are reshaping our lives, our democracies, and our sense of truth. From unpacking the present challenge around social media feeds to AI systems competing for our time, intimacy, and attention, no technology topic is out of bounds. Along the way, they also debate AI pause letters, why incentives always eat intentions, and how to design new institutional frameworks for a future where AI truly elevates human agency, compassion, and wisdom. If everything breaks humanity’s way, what becomes possible? Tune in to find out. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/