The Male Room with Dr. Jesse Mills

Dr. Mills is joined by reproductive urologist Dr. Jim Smith, a longtime colleague and leading expert in male fertility and men’s health. Together, they break down what a semen analysis actually measures, why quality and timing matter, and why men shouldn’t wait a year into the fertility journey to get checked. Dr. Smith also explains sperm cryopreservation — who should consider banking, how long it lasts, and why access remains a major barrier. Plus, they'll bust the biggest myths about what “kills” sperm, explain why semen can be a window into overall health, and offer a surprisingly practical prescription for better fertility.
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Dr. Mills sits down with hormone therapy physician and entrepreneur Dr. Peter Fotinos to unpack the difference between “hormone replacement” and true hormone optimization. They dig into how studies like the Women’s Health Initiative shaped decades of fear, and why symptoms and lived experience sometimes matter more than a single lab cutoff. The conversation also tackles common pitfalls of “testosterone mill” medicine (including routine aromatase inhibitors), plus what’s changing in women’s hormone care and why testosterone matters for women beyond libido. Finally, Dr. Fotinos shares how he’s scaling more responsible, check-in-driven telehealth—and what proactive medicine can look like for the everyday guy staring down metabolic syndrome.
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Dr. Jesse Mills sits down with gastroenterologist-turned-biotech leader Dr. Josh Ofman, president of GRAIL, the company behind a groundbreaking blood test designed to detect dozens of cancers early by analyzing DNA shed by tumors. They break down how multi-cancer early detection works, who should consider testing (even before age 50), and how the technology fits into the larger—and often confusing—longevity conversation. The episode also tackles concerns about over-screening, false positives, and why waiting decades for perfect data may cost lives today.
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Dr. Mills is joined by celebrity nutritionist and gut-health expert Dr. Daryl Gioffre to break down what’s really driving America’s acid reflux epidemic—and why the root cause is often too little stomach acid, not too much. After revealing the deeply personal story that pushed him into this work following his father’s battle with esophageal cancer, Dr. Gioffre shares practical strategies to support digestion and protect the esophagus — from the “three-hour rule” before bed to simple soothing tools like teas, honey, and magnesium. The conversation also gets into why sugar is so hard to quit, how ultra-processed foods (and “gluten-free” swaps) can backfire, and how to make realistic upgrades without white-knuckling your way through life—including how you might keep your coffee and calm your gut.
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Dr. Steve Poulter is back for Part 2 of our conversation, and this time we go straight to what he calls the hidden engine behind so much male anxiety, isolation, and anger: shame. Dr. Mills and Dr. Poulter break down how shame takes root early, why men often externalize it in ways that damage relationships, and why “anger management” is often really “shame management.” Plus, Dr. Poulter shares practical ways to get out of the “invisible/disrespected” spiral and explains why naming shame—especially around trauma—can be the turning point that finally lets healing (and even marriages) move forward.
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